Problemas
Mark for Review Glycogen synthetase kinase 3 beta is a protein kinase that has been implicated,in many types of cancer. Depending on the cell type, the gene for glycogen synthetase kinage 3 beta (GSK39) canact either as an oncogene or as a turnor suppressor. Which of the following best predicts how GSK3g mutations can lead to the development of cance? A Cells with inactive GSK3B fail to trigger apoptosis. B Cells with inactive GSK39 fail to proceed past the the Gz/M checkpoint. G_(2)/M C Cells with overactive GSK3B are more likely to repair DNA damage. D square
Roztwór
Luciana
veterano · Tutor durante 11 años
4.6
(140 Votos)
Respuesta
A
Explicación
## Step 1: Understand the role of GSK3β in cell regulation.Glycogen synthetase kinase 3 beta (GSK3β) is a protein kinase that plays a crucial role in regulating cell growth and apoptosis. It can act as either an oncogene or a tumor suppressor depending on the cell type.## Step 2: Analyze the impact of GSK3β mutations on cancer development.Mutations in GSK3β can lead to its inactivation or overactivity, which can disrupt normal cellular processes and contribute to cancer development.## Step 3: Evaluate the given options based on the role of GSK3β.- Option A: Inactive GSK3β failing to trigger apoptosis could lead to uncontrolled cell growth and cancer.- Option B: Inactive GSK2/M checkpoint is less likely to directly lead to cancer.- Option C: Overactive GSK3β repairing DNA damage is not a typical mechanism for cancer development.- Option D: Inactive GSK3β leading to increased cell proliferation is a plausible mechanism for cancer development.## Step 4: Determine the best prediction for how GSK3β mutations can lead to cancer.The most likely scenario is that inactive GSK3β fails to trigger apoptosis, allowing cells with mutations to proliferate uncontrollably and potentially develop into cancer.