Mark for Review Glycogen synthetase kinase 3 beta is a protein kinase that has been implicated,in many types of cancer. Depending on the cell type, the gene for glycogen synthetase kinage 3 beta (GSK39) canact either as an oncogene or as a turnor suppressor. Which of the following best predicts how GSK3g mutations can lead to the development of cance? A Cells with inactive GSK3B fail to trigger apoptosis. B Cells with inactive GSK39 fail to proceed past the the Gz/M checkpoint. G_(2)/M C Cells with overactive GSK3B are more likely to repair DNA damage. D square

## Step 1: Understand the role of GSK3β in cell regulation.<br />Glycogen synthetase kinase 3 beta (GSK3β) is a protein kinase that plays a crucial role in regulating cell growth and apoptosis. It can act as either an oncogene or a tumor suppressor depending on the cell type.<br /><br />## Step 2: Analyze the impact of GSK3β mutations on cancer development.<br />Mutations in GSK3β can lead to its inactivation or overactivity, which can disrupt normal cellular processes and contribute to cancer development.<br /><br />## Step 3: Evaluate the given options based on the role of GSK3β.<br />- Option A: Inactive GSK3β failing to trigger apoptosis could lead to uncontrolled cell growth and cancer.<br />- Option B: Inactive GSK2/M checkpoint is less likely to directly lead to cancer.<br />- Option C: Overactive GSK3β repairing DNA damage is not a typical mechanism for cancer development.<br />- Option D: Inactive GSK3β leading to increased cell proliferation is a plausible mechanism for cancer development.<br /><br />## Step 4: Determine the best prediction for how GSK3β mutations can lead to cancer.<br />The most likely scenario is that inactive GSK3β fails to trigger apoptosis, allowing cells with mutations to proliferate uncontrollably and potentially develop into cancer.