What is the main transformation that occurs during glycolysis? Glycolysis produces ATP and pyruvate by oxidizing water. Glycolysis produces ATP and pyruvate by oxidizing glucose and NAD^+ Glycolysis produces pyruvate, ATP, and NADH by oxidizing glucose Glycolysis produces CO_(2) ATP, and pyruvate by reducing glucose.

The correct answer is: Glycolysis produces pyruvate, ATP, and NADH by oxidizing glucose.<br /><br />During glycolysis, one molecule of glucose is broken down into two molecules of pyruvate. This process also produces a net gain of two ATP molecules and two NADH molecules. The oxidation of glucose is the main transformation that occurs during glycolysis.