1. Does a gene mutation or a chromosome mutation cause alkaptonuria? Explain. 2. Is alkaptonuria a sex-linked trait? Explain. 3. Can the AA genotype or the Aa genotype be determined by using a biochemica test to predict patterns of inheritance in members of the next generation? Explain.

1. Alkaptonuria is caused by a gene mutation. It is a rare genetic disorder that affects the body's ability to process certain amino acids called phenylalanine and tyrosine. The mutation occurs in the gene that produces an enzyme called homogentisate 1,2-dioxygenase, which is responsible for breaking down these amino acids. When the enzyme is not functioning properly, it leads to the buildup of homogentisic acid in the body, causing the symptoms of alkaptonuria.<br /><br />2. Alkaptonuria is not a sex-linked trait. It is an autosomal recessive disorder, meaning that both copies of the gene must be mutated for an individual to be affected. This means that it can affect both males and females equally.<br /><br />3. The AA genotype or the Aa genotype cannot be determined by using a biochemical test to predict patterns of inheritance in members of the next generation. Biochemical tests can only detect the presence or absence of a particular protein or enzyme, but they cannot determine the specific genetic makeup of an individual. To determine the genotype, genetic testing methods such as DNA sequencing or genetic testing kits can be used.